2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Payload

ADC Cytotoxin

ADC Payload

Related Products

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ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.

There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.

ADC Payload Isoform Specific Products:

ADC Payload Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131058
    Muscotoxin A
    Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death.
    Muscotoxin A
  • HY-132164A
    Gly-7-MAD-MDCPT hydrochloride
    		98.27%
    Gly-7-MAD-MDCPT (Compound 4b) hydrochloride is an anticancer agent. Gly-7-MAD-MDCPT hydrochloride is a Camptothecin (HY-16560) compound, which shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM.
    Gly-7-MAD-MDCPT hydrochloride
  • HY-126678
    Dimethyl-SGD-1882
    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication.
    Dimethyl-SGD-1882
  • HY-177546
    DBCO-PEG3-GGFG-Exatecan
    DBCO-PEG3-GGFG-Exatecan is a derivative of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
    DBCO-PEG3-GGFG-Exatecan
  • HY-132180
    Seco-DUBA hydrochloride
    Seco-DUBA hydrochloride is a toxin for ADC drug SYD985.
    Seco-DUBA hydrochloride
  • HY-13631AS1
    Exatecan-d3 mesylate
    Exatecan-d3 (DX8951f-d3) mesylate is deuterium-labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL.
    Exatecan-d<sub>3</sub> mesylate
  • HY-175615
    RSL3-NH2
    RSL3-NH2 is a GPX4 inhibitor and Ferroptosis inducer. RSL3-NH2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
    RSL3-NH2
  • HY-177548
    Fmoc-Val-Cit-PAB-Exatecan
    Fmoc-Val-Cit-PAB-Exatecan is a precursor form of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
    Fmoc-Val-Cit-PAB-Exatecan
  • HY-126142
    Top1 inhibitor 1
    		99.67%
    Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC50 value of 29 nM.
    Top1 inhibitor 1
  • HY-132162B
    7-MAD-MDCPT TFA
    7-MAD-MDCPT TFA, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
    7-MAD-MDCPT TFA
  • HY-176843
    eIF4A-IN-2
    eIF4A-IN-2 (Compound 93) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
    eIF4A-IN-2
  • HY-160598
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45) is a camptothecin compound that can inhibit cell proliferation, with an IC50 of 2.92 ng/mL for MDA‑MB‑468 cells. Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol can be used for the research of cancer.
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol
  • HY-130960
    Tubulysin IM-3
    Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.
    Tubulysin IM-3
  • HY-160597
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ol
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ol (Compound 79) is an exatecan (HY-13631) derivative that can be used as a payload in drug conjugates. Exatecan-amide-bicyclo[1.1.1]pentan-1-ol has significant inhibitory activity against a variety of tumor cell lines.
    Exatecan-amide-bicyclo[1.1.1]pentan-1-ol
  • HY-156249
    NMS-P528
    NMS-P528 is a Duocarmycin derivative that can be used as an ADC payload. NMS-P528 can be used to synthesize NMS-P945.
    NMS-P528
  • HY-13631N
    (9R)-Exatecan
    (9R)-Exatecan (DX8951f) is the (1R,9S) stereoisomer of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
    (9R)-Exatecan
  • HY-164787
    N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine
    N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine (Compound 14) is a tubulin polymerization inhibitor that can be used as an ADC payload.
    N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine
  • HY-W768912
    Paclitaxel-13C6
    Paclitaxel-13C6 is the 13C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy.
    Paclitaxel-<sup>13</sup>C<sub>6</sub>
  • HY-176844
    eIF4A-IN-3
    eIF4A-IN-3 (Compound 71E) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-3 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
    eIF4A-IN-3
  • HY-15581S
    MMAD-d8
    		98.95%
    MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
    MMAD-d<sub>8</sub>
Cat. No. Product Name / Synonyms Application Reactivity
ADC Payload Isoform Comparison

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