2. Signaling Pathways
  3. Antibody-drug Conjugate/ADC Related
  4. ADC Payload

ADC Cytotoxin

ADC Payload

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ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.

There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.

ADC Payload Isoform Specific Products:

ADC Payload Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W768912
    Paclitaxel-13C6
    Paclitaxel-13C6 is the 13C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy.
    Paclitaxel-<sup>13</sup>C<sub>6</sub>
  • HY-176844
    eIF4A-IN-3
    eIF4A-IN-3 (Compound 71E) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-3 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
    eIF4A-IN-3
  • HY-15581S
    MMAD-d8
    		98.95%
    MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.
    MMAD-d<sub>8</sub>
  • HY-133570
    17-AEP-GA
    17-AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. ADCs Toxin.
    17-AEP-GA
  • HY-160806
    (5-Cl)-Exatecan
    (5-Cl)-Exatecan (compound 1-5) is a potent DNA topoisomerase inhibitor used in cancer research. (5-Cl)-Exatecan is an ADC Cytotoxin.
    (5-Cl)-Exatecan
  • HY-106338
    Polyketomycin
    Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities.
    Polyketomycin
  • HY-126664
    Azonafide-PEABA
    Azonafide-PEABA is a cytotoxic agent moiety.
    Azonafide-PEABA
  • HY-148555
    AXC-879
    AXC-879, a TLR agonist (EC50: 157.2 nM). AXC-879 is an ADC Cytotoxin and can be used for ADC synthesis.
    AXC-879
  • HY-W744577
    Dexamethasone acetate-d5
    Dexamethasone acetate-d5 (Dexamethasone 21-acetate-d5; Hexadecadrol acetate-d5) is the deuterium labeled Dexamethasone acetate (HY-14648A). Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
    Dexamethasone acetate-d<sub>5</sub>
  • HY-16560R
    Camptothecin (Standard)
    Camptothecin (Standard) (Campathecin (Standard)) is the analytical standard of Camptothecin (HY-16560). This product is intended for research and analytical applications. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
    Camptothecin (Standard)
  • HY-150074
    STING agonist-18
    STING agonist-18 (compound 1a) can be used for synthesis of antibody-drug conjugates (ADCs), such Trastuzumab (HY-P9907) conjugate.
    STING agonist-18
  • HY-156642
    (1-OH)-Exatecan
    (1-OH)-Exatecan is a quinoline ring compound. (1-OH)-Exatecan has substantial antiproliferative effects. (1-OH)-Exatecan can be used for cancer diseases research.
    (1-OH)-Exatecan
  • HY-133541
    Glucopiericidin A
    Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts.
    Glucopiericidin A
  • HY-19474R
    Maytansinol (Standard)
    Maytansinol (Standard) is the analytical standard of Maytansinol. This product is intended for research and analytical applications. Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2].
    Maytansinol (Standard)
  • HY-106146
    Paclitaxel ceribate
    Paclitaxel ceribate is the ester form of paclitaxel, a natural antineoplastic agent that stabilizes tubulin polymerization. Paclitaxel causes mitotic arrest and induces apoptosis, ultimately leading to cell death. Paclitaxel also induces autophagy.
    Paclitaxel ceribate
  • HY-176777
    7-Methylol-9-methoxy-10-F-camptothecin
    7-Methylol-9-methoxy-10-F-camptothecin (Compound D6-1) is a derivative of Camptothecin (HY-16560). 7-Methylol-9-methoxy-10-F-camptothecin can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs).
    7-Methylol-9-methoxy-10-F-camptothecin
  • HY-18987
    Duocarmycin MA
    Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.
    Duocarmycin MA
  • HY-130997
    17-GMB-APA-GA
    17-GMB-APA-GA is an ADC Cytotoxin. 17-GMB-APA-GA is a potent HSP90 inhibitor and used for latent T. gondii infection research.
    17-GMB-APA-GA
  • HY-160885
    NH2-Gly-PAB-Exatecan-D-glucuronic acid
    NH2-Gly-PAB-Exatecan-D-glucuronic acid (Compound 8) is an intermediate, which reacts with NHS group to form drug-linker conjugate for ADC, Mal-Gly-PAB-Exatecan-D-glucuronic acid (HY-153179).
    NH2-Gly-PAB-Exatecan-D-glucuronic acid
  • HY-148193
    Tubulin polymerization-IN-38
    Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs.
    Tubulin polymerization-IN-38
Cat. No. Product Name / Synonyms Application Reactivity
ADC Payload Isoform Comparison

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